In an effort to keep the playing field level for Destiny 2 on PC, support for third-party streaming and game capture applications will be limited.
Bungie outlined the restrictions in a post on its official site, noting the Game Capture mode of programs like XSplit and OBS are not supported. However, you’ll be able to use the Screen Capture and Window Capture modes in OBS and XSplit while playing in Windowed Mode.
Other game capture programs, like Razer Cortex, Fraps and Dxtory have similar limitations.
Those who wish to capture footage of Destiny 2 while playing in Exclusive Fullscreen can use a dedicated streaming PC, as well as capture hardware like Elgato and AVerMedia. Bungie also notes that both AMD ReLive and NVIDIA Shadowplay are supported.